General Information

  • ID:  hor000845
  • Uniprot ID:  A0A6I8T5H9
  • Protein name:  Ecdysis triggering hormone-1b
  • Gene name:  5572299
  • Organism:  Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
  • Family:  NA
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Stegomyia (subgenus), Aedes (genus), Aedini (tribe), Culicinae (subfamily), Culicidae (family), Culicoidea (superfamily), Culicomorpha (infraorder), Nematocera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  DETPGFFIKLSKSVPRI
  • Length:  17(18-34)
  • Propeptide:  MMKFILLLVALVTLAVADETPGFFIKLSKSVPRIGRRGDFENFFLKQSKSVPRIGRRSGLFTEHSPAQDNSNWFERFMRPAKRPISTPQTENGKLYSKVRPLDLHHIIDILSDDLFFGSDLKFISWDVLDEALEEDPELMGKLSALARDKEVHQLKQLLTENKDELVQYVPLESGTSDMHSNKAYIYRTDRDEQNAELNKEKIEYQQ
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-A0A6I8T5H9-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor000845_AF2.pdbhor000845_ESM.pdb

Physical Information

Mass: 221982 Formula: C90H144N22O25
Absent amino acids: ACHMNQWY Common amino acids: FIKPS
pI: 9.53 Basic residues: 3
Polar residues: 4 Hydrophobic residues: 6
Hydrophobicity: -15.29 Boman Index: -2522
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 85.88
Instability Index: 631.76 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  20163154
  • Title:  Neuropeptidomics of the Mosquito Aedes Aegypti